ATOMIC ABSORPTION SPECTROMETRIC DETERMINATION OF PHENYLPROPANOLAMINE HCL IN PURE SOLUTION AND IN PHARMACEUTICAL PREPARATIONS BASED ON ION-PAIR FORMATION WITH SODIUM TETRAPHENYLBORON

Abstract

A new simple, rapid, accurate and precise method for the determination of phenylpropanolamine hydrochloride using atomic absorption spectrometry has been developed. The method is based on precipitation of the ion-associate complex formed from the reaction of phenylpropanolamine hydrochloride drug with sodium tetraphenyl boron reagent and the precipitate has been used for the quantitative analysis of the drug. The reacted boron in precipitate and the excess, unreacted, boron ions in the saturated solutions will be determined using direct and indirect atomic absorption spectrometry.

The precipitated ion associate was subjected to elemental analyses and metal content determination for elucidation of its structure. The effect of pH, ionic strength and temperature on precipitation was carefully studied and the solubility of the solid ion associate complex has been measured at optimum conditions and its solubility product was calculated. The present method has been successfully applied for the determination of the phenylpropanolamine hydrochloride drug in pure solution and in its pharmaceutical dosage forms.