Determination Of Urea, Creatinine And Cardiac Enzymes Levels Before And After Hemodialysis

Abstract

#Chronic kidney disease (CKD) has been described as a global health concern. A complex inter-relationship exists between the kidney and the heart. This study was aimed to determine the pre- and post- dialysis levels of urea, creatinine and cardiac enzymes among Yemeni patients undergoing intermittent maintenance hemodialysis. Fifty Yemeni subjects, aged 18-65 years, diagnosed with chronic renal failure (CRF) and undergoing intermittent maintenance hemodialysis (MHD) for at least six months at the Dialysis Unit of Al-Thawra hospital in Ibb city were enrolled in this study. Non fasting blood samples were collected and analyzed for serum urea, creatinine creatine kinase (CK), aspartate aminotransferase (AST) and lactate dehydregenase (LDH). The mean urea pre- and immediately post-dialysis was 20.9 ± 8.7 and 10.2 6.4 mmol/L, respectively. The mean creatinine pre- and immediately post dialysis was 884 ± 110 and 324 ± 96 µmol/L, respectively. Levels of urea and creatinine were decreased significantly (P<0.05) by about 51% and 63% respectively. Levels of AST, CK and LDH were increased non significantly (P>0.05) by about 121%, 89% and 39% respectively. These results show that urea and creatinine were removed by hemodialysis. These results also confirm increased levels of serum cardiac enzymes, which are only roughly proportional to the extent of tissue disorder and / or tissue damage. Furthermore, all above enzymes are not specific indicators for only cardiac muscle damage. Researchers suggested that, the use of cardiac enzymes only as indicators for the extent of cardiac disorder and/or cardiac tissue damage in hemodialysis patients is inadequate.